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Kiran R. Chaudhari, Abhinesh Kumar, Vinoth Kumar Megraj Khandelwal, Anil K. Mishra, Jukka Monkkonen and Rayasa S. Ramachandra Murthy Targeting Efficiency and Biodistribution of Zoledronate Conjugated Docetaxel Loaded Pegylated PBCA Nanoparticles for Bone Metastasis Advanced Functional Materials 22

Version of Record online: 12 JUN 2012 | DOI: 10.1002/adfm.201102357

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An anionic polymerization technique is used to prepare docetaxel (DTX)-loaded, zoledronic acid (ZOL)-conjugated polyethylene glycol (PEG)ylated polybutyl cyanoacrylate (PBCA) nanoparticles (NPs). The NPs show enhanced cytotoxicity due to higher uptake following ZOL-mediated endocytosis. PBCA-PEG-ZOL NP distribution in tumor infected bone is high compared to the normal bone. Thus, ZOL-conjugated NPs provide efficient and targeted delivery of DTX, with synergistic effects.

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