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Kai Su, Ting Ting Lau, Wenyan Leong, Yihong Gong and Dong-An Wang Creating a Living Hyaline Cartilage Graft Free from Non-Cartilaginous Constituents: An Intermediate Role of a Biomaterial Scaffold Advanced Functional Materials 22

Article first published online: 9 JAN 2012 | DOI: 10.1002/adfm.201102884

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The living hyaline cartilage graft (LhCG) fabrication process is studied. The microtissues undergoing phase transfer cell culture (PTCC) interact and secrete extracellular matrices (ECMs), forming an intricate interpenetrating network of ECM within the hydrogel scaffold. With the removal of the alginate scaffold, the structural integrity of the construct remains intact and a pure, scaffold-free LhCG is formed that is ready for implantation.

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