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Poornima Kolhar and Samir Mitragotri Polymer Microparticles Exhibit Size and Shape Dependent Accumulation around the Nucleus after Endocytosis Advanced Functional Materials 22

Version of Record online: 23 MAY 2012 | DOI: 10.1002/adfm.201102918

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The intracellular accumulation and subsequent spatial segregation of spherical and rod-shaped microparticles are studied. Both spherical and rod-shaped particles exhibit perinuclear accumulation upon cellular internalization; however binary mixtures of particles spatially segregate in the cytoplasm based on their shape and size. Larger particles exhibit preferential accumulation closer to the nucleus.

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