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Kun Ma, Dong-Dong Wang, Yiyang Lin, Jianglin Wang, Valery Petrenko and Chuanbin Mao Synergetic Targeted Delivery of Sleeping-Beauty Transposon System to Mesenchymal Stem Cells Using LPD Nanoparticles Modified with a Phage-Displayed Targeting Peptide Advanced Functional Materials 23

Version of Record online: 9 OCT 2012 | DOI: 10.1002/adfm.201102963

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A liposome protamine/DNA lipoplex integrated with a nuclear localization signal (NLS) peptide and rMSC-homing peptide is constructed for targeted delivery of transposon system to rat mesenchymal stem cells (rMSCs). A phage display technique is employed to identify the rMSC-homing peptide, which targets the MSCs. Both the NLS peptide and rMSC-homing peptide can execute a synergetic effect to promote transfection activity.

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