Kun Ma, Dong-Dong Wang, Yiyang Lin, Jianglin Wang, Valery Petrenko and Chuanbin Mao Synergetic Targeted Delivery of Sleeping-Beauty Transposon System to Mesenchymal Stem Cells Using LPD Nanoparticles Modified with a Phage-Displayed Targeting Peptide Advanced Functional Materials 23
A liposome protamine/DNA lipoplex integrated with a nuclear localization signal (NLS) peptide and rMSC-homing peptide is constructed for targeted delivery of transposon system to rat mesenchymal stem cells (rMSCs). A phage display technique is employed to identify the rMSC-homing peptide, which targets the MSCs. Both the NLS peptide and rMSC-homing peptide can execute a synergetic effect to promote transfection activity.
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