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Dmitry V. Volodkin, Stephan Schmidt, Paulo Fernandes, Natalia I. Larionova, Gleb B. Sukhorukov, Claus Duschl, Helmuth Möhwald and Regine von Klitzing One-Step Formulation of Protein Microparticles with Tailored Properties: Hard Templating at Soft Conditions Advanced Functional Materials 22

Version of Record online: 8 FEB 2012 | DOI: 10.1002/adfm.201103007

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Monodisperse microparticles with adjustable diameter composed from pure protein (insulin or catalase) are prepared under gentle conditions by hard-templating on porous decomposable CaCO3 microtemplates via isoelectric precipitation followed by pH- or EDTA-mediated template removal. The mechanism of the particle formation, mechanical properties, protein release, and potential for drug delivery applications are addressed.

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