Marie-Luce De Temmerman, Joanna Rejman, Bart Lucas, Roosmarijn E. Vandenbroucke, Claude Libert, Jo Demeester and Stefaan C. De Smedt Modulation of Dendritic Cells by Lipid Grafted Polyelectrolyte Microcapsules Advanced Functional Materials 22
Surface-functionalized polyelectrolyte microcapsules are of interest for the simultaneous delivery of antigens and immunopotentiators for vaccination. Layer-by-layer (LbL) assembled dextran sulfate/poly-L-arginine microcapsules grafted at the surface with immunomodulating lipids by incubation with liposomes are presented. Their effect on dendritic cells shows the feasibility to deliver lipophilic immunopotentiators by LbL capsules to enhance and steer the type of immune response.
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