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Dongmei Ren, Mercè Dalmau, Arlo Randall, Matthew M. Shindel, Pierre Baldi and Szu-Wen Wang Biomimetic Design of Protein Nanomaterials for Hydrophobic Molecular Transport Advanced Functional Materials 22

Article first published online: 23 APR 2012 | DOI: 10.1002/adfm.201200052

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A biomimetic strategy that encapsulates organic molecules into a protein nanocapsule by engineering non-native hydrophobicity into the interior of the capsule is demonstrated. These complexes enable delivery of drug molecules to cancer cells. This novel approach may be broadly utilized to attach guest molecules non-covalently to other protein-based materials for molecular transport and has applications in bionanotechnology.

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