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Beatriz Trastoy, Daniel A. Bonsor, M. Eugenia Pérez-Ojeda, M. Luisa Jimeno, Alejandro Méndez-Ardoy, José Manuel García Fernández, Eric J. Sundberg and Jose Luis Chiara Synthesis and Biophysical Study of Disassembling Nanohybrid Bioconjugates with a Cubic Octasilsesquioxane Core Advanced Functional Materials 22

Version of Record online: 24 APR 2012 | DOI: 10.1002/adfm.201200423

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Polyhedral oligosilsesquioxanes (POSS)-based cubic glycoclusters (glyco-POSS) are readily obtained by “click” chemistry. These nanohybrid bioconjugates slowly disassemble under physiological conditions. The disassembling process offers an important advantage for POSS conjugates over other nanoparticle conjugates intended for in vivo applications in terms of the expected rapid clearance from the body and low toxicity of their organosilane fragments, thus preventing bioaccumulation and saturation of complementary receptors.

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