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Ryan F. Donnelly, Thakur Raghu Raj Singh, Martin J. Garland, Katarzyna Migalska, Rita Majithiya, Cian M. McCrudden, Prashant Laxman Kole, Tuan Mazlelaa Tuan Mahmood, Helen O. McCarthy and A. David Woolfson Hydrogel-Forming Microneedle Arrays for Enhanced Transdermal Drug Delivery Advanced Functional Materials 22

Article first published online: 9 JUL 2012 | DOI: 10.1002/adfm.201200864

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Microneedle arrays prepared from crosslinked polymers, which contain no drug themselves, are described. They rapidly take up skin interstitial fluid upon skin insertion to form continuous, unblockable, hydrogel conduits from attached patch-type drug reservoirs to the dermal microcirculation. This technology has the potential to further enhance the capabilities of microneedle strategies for transdermal drug delivery, while bypassing current difficulties.

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