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Michael P. Cuchiara, Daniel J. Gould, Melissa K. McHale, Mary E. Dickinson and Jennifer L. West Integration of Self-Assembled Microvascular Networks with Microfabricated PEG-Based Hydrogels Advanced Functional Materials 22

Article first published online: 20 JUN 2012 | DOI: 10.1002/adfm.201200976

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The most significant tissue engineering barrier is insufficient vascularization. A microfluidic hydrogel is integrated with a self-assembling pro-vasculogenic co-culture to control vessel establishment and create an anastomotic interface for integration with fabricated microchannels. Vessel development is temporally regulated. It is further shown that transport within these regions shifts from diffusion to vessel-supported convective movement.

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