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Li Zhao, Tokuhiro Chano, Shigehiro Morikawa, Yukie Saito, Akihiko Shiino, Sawako Shimizu, Takuro Maeda, Takayoshi Irie, Shuji Aonuma, Hidetoshi Okabe, Takahide Kimura, Toshiro Inubushi and Naoki Komatsu Hyperbranched Polyglycerol-Grafted Superparamagnetic Iron Oxide Nanoparticles: Synthesis, Characterization, Functionalization, Size Separation, Magnetic Properties, and Biological Applications Advanced Functional Materials 22

Version of Record online: 7 AUG 2012 | DOI: 10.1002/adfm.201201060

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Superparamagnetic iron oxide nanoparticles (SPIONs) are directly functionalized with polyglycerol (PG) using ring-opening polymerization of glycidol to obtain good solubility in pure water and in a phosphate buffer solution. The resulting SPION-PG is further functionalized through multistep organic transformations to immobilize a targeting peptide on the surface. The targeting effect is demonstrated in cell experiments.

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