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Kanhu C. Barick, Sarika Singh, Neena V. Jadhav, Dhirendra Bahadur, Badri N. Pandey and Puthusserickal A. Hassan pH-Responsive Peptide Mimic Shell Cross-Linked Magnetic Nanocarriers for Combination Therapy Advanced Functional Materials 22

Article first published online: 3 JUL 2012 | DOI: 10.1002/adfm.201201140

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The design and development of water dispersible, pH responsive peptide mimic shell cross-linked magnetic nanocarriers with functionalized exteriors (amine and carboxyl) for conjugation of drugs is reported. Specifically, the high loading affinity of nanocarriers for an anticancer drug (doxorubicin), their sustained release profiles, magnetic-field-induced heating, low toxicity, and good cellular internalization make them suitable for combination therapy involving hyperthermia and chemotherapy.

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