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Quan Zhang, Fang Liu, Kim Truc Nguyen, Xing Ma, Xiaojun Wang, Bengang Xing and Yanli Zhao Multifunctional Mesoporous Silica Nanoparticles for Cancer-Targeted and Controlled Drug Delivery Advanced Functional Materials 22

Article first published online: 30 JUL 2012 | DOI: 10.1002/adfm.201201316

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Multifunctional mesoporous silica nanoparticles are developed in order to deliver anticancer drugs to specific cancer cells in a targeted and controlled manner. Doxorubicin-loaded nanoparticles containing folate target units can be efficiently trapped by folate-receptor-rich HeLa cancer cells through receptor-mediated endocytosis, leading to the release of doxorubicin triggered by acidic endosomal pH and intracellular glutathione for apoptosis.

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