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Jae Sam Lee and Ching-Hsuan Tung Enhancing the Cellular Delivery of Nanoparticles Using Lipo-Oligoarginine Peptides Advanced Functional Materials 22

Version of Record online: 27 JUL 2012 | DOI: 10.1002/adfm.201201345

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Gold nanoparticles (AuNPs) are functionalized by conjugating a hydrophobic fatty acid moiety and hydrophilic oligoarginine cell penetrating peptide on their surface to enhance cellular uptake and intracellular localization into cells. AMLPs (AuNPs conjugated with a myristoyl acid and an oligoarginine group) are effectively delivered into intracellular compartments of a cell without detectable cellular toxicity.

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