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Peter C. DeMuth, Wilfredo F. Garcia-Beltran, Michelle Lim Ai-Ling, Paula T. Hammond and Darrell J. Irvine Composite Dissolving Microneedles for Coordinated Control of Antigen and Adjuvant Delivery Kinetics in Transcutaneous Vaccination Advanced Functional Materials 23

Article first published online: 23 AUG 2012 | DOI: 10.1002/adfm.201201512

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Composite polymer microneedles encapsulating drug-loaded, controlled-release poly(lactide-co-glycolide) (PLGA) matrices in a rapidly soluble poly(acrylic acid) (PAA) matrix provide rapid transcutaneous implantation of long-lived depots for sustained delivery of vaccines and drug cargos in vivo. Microneedle delivery of a rationally designed subunit vaccine formulation enhances adaptive immunity relative to traditional needle-based administration.

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