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Yan Liu, Dan Luo, Xiao-Xing Kou, Xue-Dong Wang, Franklin R. Tay, Yin-Lin Sha, Ye-Hua Gan and Yan-Heng Zhou Hierarchical Intrafibrillar Nanocarbonated Apatite Assembly Improves the Nanomechanics and Cytocompatibility of Mineralized Collagen Advanced Functional Materials 23

Version of Record online: 16 OCT 2012 | DOI: 10.1002/adfm.201201611

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Nanoscale replication of the hierarchical organization of minerals in naturally mineralized tissues is successfully achieved by using a coprecipitation procedure based on two biomimetic analogs. This highly ordered mineralized collagen matrix, with improved nanomechanics and cytocompatibility, offers the opportunity for its potential use as a scaffold in bone grafting and tissue engineering.

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