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Oommen P. Oommen, Shujiang Wang, Marta Kisiel, Marije Sloff, Jöns Hilborn and Oommen P. Varghese Smart Design of Stable Extracellular Matrix Mimetic Hydrogel: Synthesis, Characterization, and In Vitro and In Vivo Evaluation for Tissue Engineering Advanced Functional Materials 23

Article first published online: 12 OCT 2012 | DOI: 10.1002/adfm.201201698

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An intrinsically stabilized hydrazone crosslinked extracellular matrix (ECM) mimetic hyaluronan hydrogel exhibits controlled swelling, slow enzymatic degradation, and excellent mechanical properties. These properties are achieved by fine tuning the electronic character around the hydrazone linkage. This tailored ECM mimetic hydrogel demonstrates efficient recombinant human bone morphogenetic protein-2 mediated ectopic bone formation in vivo, with oriented collagen and angiogenesis.

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