E-mail

E-mail a Wiley Online Library Link

Hongmei Li, Shann S. Yu, Martina Miteva, Christopher E. Nelson, Thomas Werfel, Todd D. Giorgio and Craig L. Duvall Matrix Metalloproteinase Responsive, Proximity-Activated Polymeric Nanoparticles for siRNA Delivery Advanced Functional Materials 23

Article first published online: 6 FEB 2013 | DOI: 10.1002/adfm.201202215

Thumbnail image of graphical abstract

A pH-responsive, smart polymeric nanocarrier (SPN) with matrix metalloproteinase (MMP)-7-dependent proximity-activated targeting (PAT) incorporates polyethylene glycol (PEG) shielding that is removable in MMP-7-rich environments (e.g., breast cancer metastases). The up-regulated MMP-7 activity in pathological tissue exposes the cationic component of the SPN polymer, triggering cell uptake. Following internalization of polymers into the endosomal pathway, pH-dependent endosomal escape facilitates cytosolic siRNA delivery.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field

Choose captcha format: Image or Audio. Click here if you need help.

SEARCH