Abdennour Abbas, Limei Tian, Jeremiah J. Morrissey, Evan D. Kharasch and Srikanth Singamaneni Hot Spot-Localized Artificial Antibodies for Label-Free Plasmonic Biosensing Advanced Functional Materials 23
Macromolecular imprinting of gold nanorods is achieved using reversible template immobilization and siloxane copolymerization. The anisotropic capping of the nanorods is used to selectively localize the protein imprints at the nanorod plasmonic hot-spots. This configuration represents the first protein-imprinted localized surface plasmon resonance nanosensor dedicated to the detection of biomarkers at clinically relevant concentrations.
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