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Alessandro Poma, Antonio Guerreiro, Michael J. Whitcombe, Elena V. Piletska, Anthony P. F. Turner and Sergey A. Piletsky Solid-Phase Synthesis of Molecularly Imprinted Polymer Nanoparticles with a Reusable Template–“Plastic Antibodies” Advanced Functional Materials 23

Article first published online: 16 JAN 2013 | DOI: 10.1002/adfm.201202397

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The first example of the solid-phase synthesis of molecularly imprinted polymer (MIP) nanoparticles is reported using an immobilized template in an automated reactor. Formation of nanoMIP by photopolymerization in a column packed with the template phase is followed by washing to remove low affinity particles. High temperature elution releases the high affinity nanoMIPs and the template phase, which can be re-used.

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