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Dongfei Liu, Ermei Mäkilä, Hongbo Zhang, Barbara Herranz, Martti Kaasalainen, Päivi Kinnari, Jarno Salonen, Jouni Hirvonen and Hélder A. Santos Nanostructured Porous Silicon-Solid Lipid Nanocomposite: Towards Enhanced Cytocompatibility and Stability, Reduced Cellular Association, and Prolonged Drug Release Advanced Functional Materials 23

Article first published online: 6 NOV 2012 | DOI: 10.1002/adfm.201202491

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Thermally hydrocarbonized porous silicon−solid lipid nanocomposites (THCPSi−SLNCs) on a ratio 1:1 prepared by the solid-in-oil-in-water emulsion solvent evaporation method are produced in order to enhance the suspensibility of the nanoparticles and the stability against aggregation in aqueous buffer solutions, as well as to increase the particle surface smoothness and cytocompatibility, reduce the particle's cellular association, increase the in vitro stability in human plasma, and prolong the loaded drug release.

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