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Seung Koo Lee and Ching-Hsuan Tung A Fabricated siRNA Nanoparticle for Ultralong Gene Silencing In Vivo Advanced Functional Materials 23

Version of Record online: 18 FEB 2013 | DOI: 10.1002/adfm.201202777

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An ultralong siRNA gene silencing effect is achieved in cells and in animal using a functionalized siRNA nanoparticle that consists of multiple siRNA and degradable polypeptide layers. Due to the slow degradation through the layers, the particles continuously release siRNA and the in vivo gene silencing effect is consistent for more than 3 weeks with only a single treatment.

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