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Marco Angarano, Simon Schulz, Martin Fabritius, Robert Vogt, Thorsten Steinberg, Pascal Tomakidi, Christian Friedrich and Rolf Mülhaupt Layered Gradient Nonwovens of In Situ Crosslinked Electrospun Collagenous Nanofibers Used as Modular Scaffold Systems for Soft Tissue Regeneration Advanced Functional Materials 23

Version of Record online: 6 FEB 2013 | DOI: 10.1002/adfm.201202816

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Water resistant, in situ crosslinked gelatin nanofibers are produced in a versatile one-step electrospinning process, using glyoxal as a crosslinking agent. The slowly progressing crosslinking reaction during electrospinning increases the solution viscosity and the average fiber diameter, thus forming gradient nonwovens. To improve the mechanical stability, the crosslinked gelatin nonwovens are laminated with perforated polycaprolactone layers.

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