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Riccardo Marega, Federica De Leo, Florent Pineux, Jacopo Sgrignani, Alessandra Magistrato, Anil Damodar Naik, Yann Garcia, Lionel Flamant, Carine Michiels and Davide Bonifazi Functionalized Fe-Filled Multiwalled Carbon Nanotubes as Multifunctional Scaffolds for Magnetization of Cancer Cells Advanced Functional Materials 23

Article first published online: 29 JAN 2013 | DOI: 10.1002/adfm.201202898

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Encapsulation of Fe phases inside multiwalled carbon nanotubes (MWCNTs) allows isolating reactive magnetic phases exerting magnetic fluid hyperthermia responses. In particular, bioconjugation of Fe@MWCNTs with monoclonal antibody Cetuximab enables the selective in vitro cancer cell sorting and stimuli-induced cytotoxicity under application of external magnetic inputs. Molecular dynamics calculations shed further light on binding modes and conformational properties of the Ab moieties linked on to the tubular carbon framework.

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