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Lindsay S. Wray, Konstantinos Tsioris, Eun Seok Gil, Fiorenzo G. Omenetto and David L. Kaplan Microfabricated Porous Silk Scaffolds for Vascularizing Engineered Tissues Advanced Functional Materials 23

Article first published online: 13 FEB 2013 | DOI: 10.1002/adfm.201202926

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A silk scaffold is patterned with porous microchannels for engineering vascularized tissues. Microchannel dimensions range from 25 to 300 μm and endothelial cells proliferate to confluence within the channels. The microchannels are enclosed with biocompatible tissue adhesive. The scaffold supports endothelial lumen formation in the enclosed microchannels and supports stem cell co-culture in the bulk space.

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