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Jan J. T. M. Swartjes, Theerthankar Das, Shahriar Sharifi, Guruprakash Subbiahdoss, Prashant K. Sharma, Bastiaan P. Krom, Henk J. Busscher and Henny C. van der Mei A Functional DNase I Coating to Prevent Adhesion of Bacteria and the Formation of Biofilm Advanced Functional Materials 23

Article first published online: 16 JAN 2013 | DOI: 10.1002/adfm.201202927

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A DNase I coating using dopamine as an intermediate layer strongly reduces bacterial adhesion and prevents biofilm formation by degradation of extracellular DNA (eDNA) in the biofilm matrix causing disruption of the matrix that holds the biofilm together, without affecting mammalian cell adhesion and proliferation.

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