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Chao Wang, Liang Cheng, Yumeng Liu, Xiaojing Wang, Xinxing Ma, Zhaoyi Deng, Yonggang Li and Zhuang Liu Imaging-Guided pH-Sensitive Photodynamic Therapy Using Charge Reversible Upconversion Nanoparticles under Near-Infrared Light Advanced Functional Materials 23

Article first published online: 31 JAN 2013 | DOI: 10.1002/adfm.201202992

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Smart charge-reversible upconversion nanoparticles are developed for pH-responsive in vivo near-infrared light -excited photodynamic therapy. While stable under normal physiological pH, highly sensitive acid-induced charge conversion of those nanoparticles is observed in slightly acidic tumor microenvironments, resulting in significantly enhanced cellular internalization of nanoparticles and remarkably improved photodynamic cancer-cell killing efficacy.

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