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Lee W. Tien, Fan Wu, Min D. Tang-Schomer, Euisik Yoon, Fiorenzo G. Omenetto and David L. Kaplan Silk as a Multifunctional Biomaterial Substrate for Reduced Glial Scarring around Brain-Penetrating Electrodes Advanced Functional Materials 23

Article first published online: 24 JAN 2013 | DOI: 10.1002/adfm.201203716

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Silk fibroin is investigated as a novel material for fabricating brain-penetrating electrodes with dynamic mechanical properties and the capacity to deliver sensitive therapeutics. Silk coatings are shown to natively reduce some markers of gliosis in vitro, and a further reduction is demonstrated by encapsulation and release of the enzyme chondroitinase ABC.

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