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Homan Kang, Sinyoung Jeong, Younggeun Park, Joonhyuk Yim, Bong-Hyun Jun, San Kyeong, Jin-Kyoung Yang, Gunsung Kim, SoonGweon Hong, Luke P. Lee, Jong-Ho Kim, Ho-Young Lee, Dae Hong Jeong and Yoon-Sik Lee Near-Infrared SERS Nanoprobes with Plasmonic Au/Ag Hollow-Shell Assemblies for In Vivo Multiplex Detection Advanced Functional Materials 23

Article first published online: 13 MAR 2013 | DOI: 10.1002/adfm.201203726

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Near-infrared-sensitive surface-enhanced Raman scattering nanoprobes (NIR SERS dots) are fabricated by forming plasmonic Au/Ag hollow-shells, which assemble on silica nanospheres. A single NIR SERS dot is capable of generating a strong SERS signal (average SERS enhancement factor value 2.8 × 105) with high reproducibility. In addition, the signals from NIR SERS dots are effectively detected from deep tissues of up to 8 mm depth and have exhibited a capability for in vivo multiplex detection in a live animal study.

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