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Yasemin Yuksel Durmaz, Yen-Ling Lin and Mohamed E. H. ElSayed Development of Degradable, pH-Sensitive Star Vectors for Enhancing the Cytoplasmic Delivery of Nucleic Acids Advanced Functional Materials 23

Version of Record online: 11 MAR 2013 | DOI: 10.1002/adfm.201203762

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A series of degradable, pH-sensitive, membrane-destabilizing, star-shaped polymers is synthesized. Star polymers are engineered to “sense” the drop in endosomal pH, which triggers the hydrolysis of acid-labile hydrazone linkages and release of membrane-active grafts that rupture the endosomal membrane and release the loaded siRNA cargo into the cytoplasm to produce the desired knockdown of targeted gene expression at both the mRNA and protein levels.

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