Dongmei Fan, Enrica De Rosa, Matthew B. Murphy, Yang Peng, Christine A. Smid, Ciro Chiappini, Xuewu Liu, Paul Simmons, Bradley K. Weiner, Mauro Ferrari and Ennio Tasciotti Tissue Engineering: Mesoporous Silicon-PLGA Composite Microspheres for the Double Controlled Release of Biomolecules for Orthopedic Tissue Engineering (Adv. Funct. Mater. 2/2012) Advanced Functional Materials 22
A new composite platform for the delivery of bioactive molecules is obtained by embedding mesoporous silicon particles in poly(DL-lactide-co-glycolide) (PLGA) microspheres. As reported on page 282 by Ennio Tasciotti and co-workers, this system can be synthesized and tuned to tailor size, density, and delivery kinetics to the application of choice. This hybrid system displays emerging features and properties that depend on the interactions of the two materials at the molecular and nanoscale.
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