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Nasim Annabi, Kelly Tsang, Suzanne M. Mithieux, Mehdi Nikkhah, Afshin Ameri, Ali Khademhosseini and Anthony S. Weiss Highly Elastic Micropatterned Hydrogel for Engineering Functional Cardiac Tissue Advanced Functional Materials 23

Article first published online: 26 APR 2013 | DOI: 10.1002/adfm.201300570

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Highly elastic hydrogels containing well-defined micropatterns are engineered from recombinant human tropoelastin, the resilience-imparting protein found in all elastic human tissues. These elastic substrates are then used to engineer biomimetic cardiac tissue constructs. The micropatterned hydrogels support the alignment, intercellular communication, and synchronous beating of cardiomyocytes by providing an elastic mechanical support that mimics their dynamic mechanical properties in vivo (scale bar: 50 μm).

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