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Fatemeh Sadat Majedi, Mohammad Mahdi Hasani-Sadrabadi, Jules John VanDersarl, Nassir Mokarram, Shahirar Hojjati-Emami, Erfan Dashtimoghadam, Shahin Bonakdar, Mohammad Ali Shokrgozar, Arnaud Bertsch and Philippe Renaud On-Chip Fabrication of Paclitaxel-Loaded Chitosan Nanoparticles for Cancer Therapeutics Advanced Functional Materials 24

Version of Record online: 5 AUG 2013 | DOI: 10.1002/adfm.201301628

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Using microfluidics to precisely regulate self-assembly conditions, a number of nanoparticle properties are tuned to optimize drug-delivery efficacy. These parameters include size, zeta potential, and pH responsiveness. These nanoparticles are stable during circulation at physiological pH, but if they encounter a tumor cell, where the pH is lower, they rapidly release their anti-cancer drug cargo

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