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Lingzhi Zhao, Juanjuan Peng, Qi Huang, Chunyan Li, Min Chen, Yun Sun, Qiuning Lin, Linyong Zhu and Fuyou Li Near-Infrared Photoregulated Drug Release in Living Tumor Tissue via Yolk-Shell Upconversion Nanocages Advanced Functional Materials 24

Article first published online: 4 SEP 2013 | DOI: 10.1002/adfm.201302133

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A near-infrared (NIR) phototrigger-controlled drug-release device (PDD) is designed using yolk-shell structured nanocages with upconversion nanophosphors as yolks and silica as shells (YSUCNP). The anticancer drug chlorambucil caged with a coumarin phototrigger is accommodated by YSUCNPs to a large loading capacity of 49 wt%. By employing NIR light with deep tissue penetration depth as stimuli, the PDD demonstrates efficacy in living tumor-bearing mice with zero premature release.

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