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Xiaohua Yu, Andrew Khalil, Phuong Ngoc Dang, Eben Alsberg and William L. Murphy Multilayered Inorganic Microparticles for Tunable Dual Growth Factor Delivery Advanced Functional Materials 24

Article first published online: 10 FEB 2014 | DOI: 10.1002/adfm.201302859

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A multilayered, mineral coated microparticle platform is developed for tunable dual growth factor delivery. Distinct release kinetics of BMP-2 and VEGF is achieved by binding the growth factors on different coating layers and manipulating the intrinsic properties of the mineral coatings. This multiple protein delivery system has immense potential in tissue engineering to better mimic the natural healing process.

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