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Min D. Tang-Schomer, Xiao Hu, Marie Hronik-Tupaj, Lee W. Tien, Michael J. Whalen, Fiorenzo G. Omenetto and David L. Kaplan Film-Based Implants for Supporting Neuron–Electrode Integrated Interfaces for The Brain Advanced Functional Materials 24

Version of Record online: 18 NOV 2013 | DOI: 10.1002/adfm.201303196

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Neuron-electrode interfaces are developed on thin silk films as brain implants. Silk films can use surface topography to induce astrocyte alignment, and microfluidic systems to generate patterned axon tracts. With built-in wire connections in the film, cortical neurons produce robust calcium responses upon electrical stimulation. These brain-compatible implants could potentially provide sustained functional neuron-electrode interfaces for the brain.

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