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Yuting Wen, Zhongxing Zhang and Jun Li Highly Efficient Multifunctional Supramolecular Gene Carrier System Self-Assembled from Redox-Sensitive and Zwitterionic Polymer Blocks Advanced Functional Materials 24

Article first published online: 18 MAR 2014 | DOI: 10.1002/adfm.201303687

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A convenient supramolecular strategy is demonstrated for building a highly efficient multifunctional gene carrier system. The system is self–assembled and integrated from two polymeric building blocks via host-guest interaction between β-cyclodextrin and adamantyl moieties, possessing the functions of disulfide bond based reduction-responsive degradation, and zwitterionic phosphorylcholine based extracellular stabilization and favorable cellular uptake.

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