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Heng-Wen Liu, Wei-Chen Huang, Chih-Sheng Chiang, Shang-Hsiu Hu, Chia-Hsin Liao, You-Yin Chen and San-Yuan Chen Arrayed rGOSH/PMASH Microcapsule Platform Integrating Surface Topography, Chemical Cues, and Electrical Stimulation for Three-Dimensional Neuron-Like Cell Growth and Neurite Sprouting Advanced Functional Materials 24

Article first published online: 4 MAR 2014 | DOI: 10.1002/adfm.201303853

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The stimulus-responsive, well-ordered rGOSH/PMASH microcapsules are arrayed into a 3-D ECM-mimic flexible substrate to accelerate the proliferation and differentiation of PC12 cells by controlling NGF release and manipulating rGOSH/PMASH microcapsule interfaces. A combination of surface topography, chemical cues, and electrical stimulation not only has positive effects on cell viability but also strongly enhances the neurite outgrowth of PC12 cells.

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