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Robert Dorresteijn, Nils Billecke, Mischa Schwendy, Sabine Pütz, Mischa Bonn, Sapun H. Parekh, Markus Klapper and Klaus Müllen Polylactide-block-Polypeptide-block-Polylactide Copolymer Nanoparticles with Tunable Cleavage and Controlled Drug Release Advanced Functional Materials 24

Article first published online: 14 MAR 2014 | DOI: 10.1002/adfm.201304074

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Triblock copolymer nanoparticle with tunable drug release. Nanocarriers based on PLLA-b-peptide-b-PLLA copolymers are proved to have exceptional material properties for controlled drug release in response to MMP-2-dependent peptide cleavage. Comparison specimens demonstrate the tunable bioactivity of these nanocarriers based on polymer constitution. As MMP-2 is selectively overexpressed in tumor tissues, this is a promising system for solid tumor cancer therapy.

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