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Chao Wang, Liang Cheng, Yumeng Liu, Xiaojing Wang, Xinxing Ma, Zhaoyi Deng, Yonggang Li and Zhuang Liu Biomedical Applications: Imaging-Guided pH-Sensitive Photodynamic Therapy Using Charge Reversible Upconversion Nanoparticles under Near-Infrared Light (Adv. Funct. Mater. 24/2013) Advanced Functional Materials 23

Article first published online: 18 JUN 2013 | DOI: 10.1002/adfm.201370119

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Smart charge-reversible upconversion nanoparticles are reported on page 3077 by Zhuang Liu and co-workers for pH-responsive, in vivo, near-infrared light excited photodynamic therapy. While stable under normal physiological pH, highly sensitive acid-induced charge conversion of the nanoparticles is observed in a slightly acidic tumor microenvironment, resulting in significantly enhanced cellular internalization of nanoparticles and remarkably improved photodynamic cancer cell killing in vitro and in vivo.

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