Oju Jeon and Eben Alsberg Micropatterning: Regulation of Stem Cell Fate in a Three-Dimensional Micropatterned Dual-Crosslinked Hydrogel System (Adv. Funct. Mater. 38/2013) Advanced Functional Materials 23
3D, dual-crosslinked, oxidized hydrogels with spatially tunable physical properties are micropatterned on page 4765 by O. Jeon and E. Alsberg. Photoencapsulated human adipose-derived stem cell proliferation rate and osteogenic and chondrogenic differentiation are found to be functions of the micropattern size. The physical properties in this system therefore introduce a new parameter for regulating various cellular behaviors, and a novel platform for studying the proliferation and differentiation of stem cells in a spatially controlled manner for tissue engineering and regenerative medicine applications.
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