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Michael Gasik, Lieve Van Mellaert, Dorothée Pierron, Annabel Braem, Dorien Hofmans, Evelien De Waelheyns, Jozef Anné, Marie-Françoise Harmand and Jozef Vleugels Reduction of Biofilm Infection Risks and Promotion of Osteointegration for Optimized Surfaces of Titanium Implants Advanced Healthcare Materials 1

Version of Record online: 15 DEC 2011 | DOI: 10.1002/adhm.201100006

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In vitro studies of Staphylococcus aureus and Staphylococcus epidermidis proliferation on titanium with different roughness, porosity, topology and hydrophilicity are reported. Materials have been tested for human osteogenic and endothelial cell adhesion, proliferation, and differentiation. Results indicate the possibility of significanly decreasing the biofilm formation in comparison with non-optimized porous titanium coatings. This presents an opportunity to manufacture implants with intrinsic reduced infection risk, yet without additional use of antibacterial substances.

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