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Qi Wang, Yongping Bao, Xiaohong Zhang, Paul R. Coxon, Upali A. Jayasooriya and Yimin Chao Uptake and Toxicity Studies of Poly-Acrylic Acid Functionalized Silicon Nanoparticles in Cultured Mammalian Cells Advanced Healthcare Materials 1

Version of Record online: 16 FEB 2012 | DOI: 10.1002/adhm.201100010

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Poly-acrylic acid grafted silicon nanoparticles are bio-compatible and can be suspended in water. No evidence of in vitro cytotoxicity is demonstrated upon exposure of cells to the nanoparticles. When incubated into mammalian cells, the nanoparticles display intense luminescence, and the cellular uptake of the nanoparticles shows a clear time dependence at higher concentrations. This study provides fundamental evidence for safe application of silicon nanoparticles, which could broaden their potential uses as cell markers in living systems and in micelle encapsulated drug-delivery systems.

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