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Aurélie Jean and George C. Engelmayr Jr. Anisotropic Collagen Fibrillogenesis Within Microfabricated Scaffolds: Implications For Biomimetic Tissue Engineering Advanced Healthcare Materials 1

Version of Record online: 15 DEC 2011 | DOI: 10.1002/adhm.201100017

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Anisotropic collagen fibrillogenesis is demonstrated within the pores of an accordion-like honeycomb poly(glycerol sebacate) tissue engineering scaffold. Confocal reflectance microscopy and image analysis demonstrate increased fibril distribution order, fibril density, and alignment in accordion-like honeycomb pores compared with collagen gelled unconstrained. Finite element modeling predicts how collagen gel and scaffold mechanics couple in matching native heart muscle stiffness and anisotropy.

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