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Axel Schloßbauer, Anna M. Sauer, Valentina Cauda, Alexandra Schmidt, Hanna Engelke, Ulrich Rothbauer, Kourosh Zolghadr, Heinrich Leonhardt, Christoph Bräuchle and Thomas Bein Cascaded Photoinduced Drug Delivery to Cells from Multifunctional Core–Shell Mesoporous Silica Advanced Healthcare Materials 1

Version of Record online: 2 APR 2012 | DOI: 10.1002/adhm.201100033

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Different bioactive molecules are released into living cells from lipid-covered mesoporous silica nanoparticles. The release is triggered by light, as the particles feature covalently attached photosensitizers as membrane-opening agents. It is demonstrated that the particles achieve endosomal escape and that they release their cargo into the cytosol.

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