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Tao Chen, Xing Guo, Xian Liu, Shuai Shi, Jie Wang, Chunli Shi, Zhiyong Qian and Shaobing Zhou A Strategy in The Design of Micellar Shape for Cancer Therapy Advanced Healthcare Materials 1

Version of Record online: 16 FEB 2012 | DOI: 10.1002/adhm.201100040

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Biodegradable poly(ether-anhydrides) micelles with filamentous, rod-like, and spherical shapes are fabricated. Of these shapes, the filamentous micelles, when loaded with doxorubicin hydrochloride, displayed the highest safety to body and the best therapeutic effect to an artificial solid tumor. This shape can therefore be assumed to be the most suitable micelle morphology in the design and engineering of drug vehicle for cancer therapy.

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