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Kai Yu, Benjamin F. L. Lai and Jayachandran N. Kizhakkedathu Carbohydrate Structure Dependent Hemocompatibility of Biomimetic Functional Polymer Brushes on Surfaces Advanced Healthcare Materials 1

Version of Record online: 16 MAR 2012 | DOI: 10.1002/adhm.201100042

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Glycocalyx mimicking glycopolymer brushes presenting mannose, galactose and glucose units were synthesized on surfaces. The developed surface coatings showed pronounced differences in their blood interaction as function of sugar units present. Surface plasmon resonance analysis showed that the total protein adsorption from human plasma was greatly reduced to 24.3 ng/cm2 on brushes presenting glucose. Glycopolymer brushes were neutral to surface induced blood coagulation with the glucose brush performing slightly better than the others.

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