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David Horna, Juan Carlos Ramírez, Anna Cifuentes, Antonio Bernad, Salvador Borrós and Manuel A. González Efficient Cell Reprogramming Using Bioengineered Surfaces Advanced Healthcare Materials 1

Version of Record online: 16 FEB 2012 | DOI: 10.1002/adhm.201200017

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A novel method for cell reprogramming is been developed by immobilizing nucleic acid transfer vectors containing free amino groups, like lentiviral particles, onto pentafluorophenyl methacrylate (PFM)-modified surfaces obtained by PFM grafting affter Ar plasma treatment. This technique is able to reprogram murine somatic cells into pluripotent cells at high efficiencies. We call these modified surfaces cell reprogramming surfaces, or CRS.

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