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Yanlan Liu, Kelong Ai, Jianhua Liu, Qinghai Yuan, Yangyang He and Lehui Lu Hybrid BaYbF5 Nanoparticles: Novel Binary Contrast Agent for High-Resolution in Vivo X-ray Computed Tomography Angiography Advanced Healthcare Materials 1

Article first published online: 11 MAY 2012 | DOI: 10.1002/adhm.201200028

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A novel CT contrast agent denoted as BaYbF5@SiO2@PEG is presented. The as-prepared nanoparticles exhibit significantly enhanced contrast efficacy relative to clinical iodinated agents and maintain higher X-ray attenuation at different voltages, suitable for diagnostic imaging of various patients. Prolonged circulation time in vivo and low toxicity mean the nanoparticles perform excellently in in-vivo X-ray CT angiography.

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