Michael W. Toepke, Nicholas A. Impellitteri, Sheeny K. Lan Levengood, Derek S. Boeldt, Ian M. Bird and William L. Murphy Regulating Specific Growth Factor Signaling Using Immobilized Branched Ligands Advanced Healthcare Materials 1
VEGF-binding peptide ligands are incorporated into hydrogel microspheres and reduce the amount of growth factor in solution. VEGF binding affinity is enhanced by creating ligands with a dimer structure. The spheres are able to knock down VEGF-mediated HUVEC growth and reduce calcium signaling. The binding interaction is reversible, allowing the spheres to be used as a VEGF delivery vehicle.
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